Nerve injury-induced protein 1 (Ninj1) is upregulated in NSCLC cells and tissues; the subpopulation of Ninj1high LCSCs exhibits the CSC-related features such as the increase of ALDH+ subpopulation, sphere-forming ability, and stemness markers; and the downstream signaling pathway Wnt/β-Catenin is also activated by Frizzled2-LRP6 assembly (78). The gene discussed is NINJ1; the disease is non-small cell lung carcinoma.