Nuclear factor erythroid 2-related factor 2 (Nrf2) is increased and Keap1 in cytoplasmic is decreased, and these changes in Nrf2 and Keap1 are correlated with the poor outcome of NSCLC patients, and increased Nrf2 may contribute to chemoresistance when using platinum-related chemotherapy (67). Here, NFE2L2 is linked to non-small cell lung carcinoma.