CDKN2A and lung cancer: EZH2 was in the upstream of NXPH4, and could activate the expression of NXPH4; then, the activated NXPH4 could downregulate the expression of CDKN2A, and the downregulated CDKN2A could regulate the cyclinD-CDK4/6-pRB-E2F signaling pathway resulting in the cell cycle activation and the promotion of proliferation and migration of lung cancer cells (70).