PIK3CA and non-small cell lung carcinoma: Rearranged during transfection (RET) rearrangements are found in 1%–2% of NSCLC patients, and the downstream signaling pathways of RET, such as PI3K/AKT, JAK-STAT, and RAS/MAPK, are associated with cell proliferation, invasion, and migration (15, 16).