SMAD3 and cancer: Meanwhile, fascin-1 is transcriptionally regulated by a variety of transcription factors (SMAD3/4, CREB, NF-κB, HIF1-α) and participates in a variety of cancer promoting signaling pathways, such as MAPK, YAP/TAZ, AKT, RSK2, etc. Therefore, fascin-1 is considered as a promising diagnostic marker and prognostic marker.