Co‐transfection of TriMix and mRNA encoding the HLA‐II targeting signal (DC‐LAMP) and the melanoma‐associated antigen fusion protein (MAGE‐A3, MAGE‐C2, tyrosinase or gp100) into autologous DC to prepare a DC vaccine (TriMixDC‐MEL) activation and promote DC maturation and function is underway (NCT01066390).286. Here, TYR is linked to melanoma.