Significantly lower expression of LCOR (ligand-dependent nuclear receptor corepressor) gene in chordoma can be caused in part by the upregulation of seven miRNAs (miR-101, miR-142, miR-144, miR-148, miR-182, miR-199a, and miR-424), which are predicted or validated regulators of the LCOR mRNA. The gene discussed is LCOR; the disease is chordoma.