PLVAP is indicated to be markedly upregulated among high grade, isocitrate dehydrogenase (IDH) wild form, non-codeleted 1p19q subform in combination with unmethylated O6-methylguanine- deoxyribonucleic acid methyltransferases (MGMT) promoter subform gliomas. The gene discussed is IDH3A; the disease is central nervous system cancer.