PTPRD and coronary artery disorder: The absence of the CREB protein in VSMCs, which makes them more susceptible to activation and death, is a common pathological response to vascular injury and may contribute to plaque development [44]; CNTNAP2 plays a key role in ischemic heart disease [45] and circulating lipid levels [46]; PTPRD has an effect on the onset and progression of CHD via acting on the glycine metabolism [47].