Synthetic biology could also contribute greatly to the IBD treatment regarding various aspects, such as microbiota-derived metabolites, microRNAs (miRNAs), mesenchymal stem cells (MSCs), calreticulin, and microbe-related methods such as LBP, FMT, bacteriophage therapy, engineered bacteria, and their functional secreted synthetic products for IBD medical implementation. This evidence concerns the gene CALR and inflammatory bowel disease.