Therefore, we analysed the cardiac function, ventricular remodelling, fibrosis, and inflammatory factors in MI mice after Se-PEG-PPG hydrogel injection, revealing that 4 weeks after Se-PEG-PPG hydrogel treatment, cardiac function was significantly restored, ventricular remodelling was significantly improved, and fibrosis of infarction region and the serum expression of IL-6 were effectively inhibited in MI mice. The gene discussed is IL6; the disease is myocardial infarction.