For example, the development of synthetic light-activated ion channels for studying neurological disorders (Beck et al., 2018), the engineering of GPCR biomarkers that trigger on diagnostic ligand association (Adeniran et al., 2018), and the design of highly ligand specific molecular on-switches that mediate CAR T-cell activity (Zajc et al., 2020). Here, TNFSF14 is linked to nervous system disorder.