For example, increased levels of Hsp60, Hsp72, Hsp90, Hsp70 and Grp94 released from adipocytes under stressful conditions have been shown to act as adipokines, linking their expression to obesity and chronic inflammation (Märker et al., 2012; Tiss et al., 2014; Sell et al., 2017). This evidence concerns the gene HSPA1A and obesity due to melanocortin 4 receptor deficiency.