In Idiopathic Pulmonary Fibrosis (IPF), one of the common interstitial lung diseases, Hsp70s were observed to be downregulated in response to an increase in the profibrotic molecules, IGFBP5 (insulin-like growth factor-binding protein 5) or (TGF β1) transforming growth factor-β1 (Sellares et al., 2019). This evidence concerns the gene IGFBP5 and interstitial lung disease.