CD274 and lung carcinoma: The most prominent ones are the proteins (ZEB1, TRAF4, TGF-β, etc.)involved in lung cancer metastasis by EMT, proteins (PD-L1, EGFR, TLR7, TLR8) involved in inhibiting the immune system, and several Wnt proteins (Wnt5b, Wnt3a) and Interleukins (IL-6, IL-8, IL-10) that allow invasion and proliferation of the tumor (Jiang et al., 2021).