Other signature molecules that form a part of the exosomes cargo from GC cells include proteins (UBR2, TRIM3, Apolipoprotein E), miRNAs (miR-423-5p, miR-155-5p, miR-27a, etc.), IncRNA (ZFAS1, LINC00152), and circRNA (ciRS-133, circ-KIAA1244) which may be utilized as characteristic biomarker for early diagnosis of gastric cancer (Fu et al., 2019). Here, APOE is linked to gastric cancer.