ANXA1 and neoplasm: Proteases, including urokinase plasminogen activator, which promotes tumor cellular invasion, and cathepsin D, and adhesion modulators, including vimentin, galectin 3-binding protein, and annexin A1, have additionally been determined in tumor-derived exosomes (Harris et al., 2015); miRNAs and different nucleic acids, that may result in malignant adjustments in target cells, had been identified in tumor cellular exosomes (Melo et al., 2014).