Generally, p53 gene deficiency combined with DNA helicase knockout results in severe phenotypes and enhanced cancer progression in mice (Lombard et al., 2000; Houghtaling et al., 2005; Mann et al., 2005; Vannier et al., 2013; Lutzmann et al., 2019), apart from in Chd1-knockout mice (Guzman-Ayala et al., 2015). Here, TP53 is linked to cancer.