RTEL1 and central nervous system cancer: However, Rtel1 IA/IA mice demonstrate accelerated tumorigenesis in the absence of p53 (Vannier et al., 2013), suggesting that Rtel1 is a potent tumor suppressor gene, which has been previously revealed by a genome-wide association study that identified it as a glioma susceptibility locus (Shete et al., 2009).