Wang, L. et al. (Wang et al., 2020) cultured Kashin-Beck disease (KBD) chondrocytes with nano-Se (SeCS) and consequently found that SeCS could reduce the apoptosis of KBD chondrocytes with the upregulation of carbohydrate sulfotransferase 12 and 15 (CHST-12, 15) uronyl 2-O-sulfotransferase (UST) on protein and mRNA level. This evidence concerns the gene CHST12 and Kashin-Beck disease.