PRKN and Parkinson disease: The two patients with PD were as follows; a juvenile form of PD caused by a biallelic copy-number neutral intragenic inversion in the PRKN gene, encoding the E3 ubiquitin ligase Parkin (Mor-Shaked et al., 2021) and a juvenile PD patient due to biallelic mutations in the PARK7 gene encoding the DJ-1 protein (Namnah et al., 2020) The fibroblasts from these patients were incubated 72 h with or without omaveloxolone and subsequently evaluated for mitochondrial function.