TNF and Sepsis: These genes are mainly involved in the cytokine–cytokine receptor interaction pathway (TNF, IL-1Β, IL-18, and CXCL8), toll-like receptor signaling pathway (TLR2, TLR9, and MYD88), NOD-like receptor signaling pathway (NLRP3), etc. Cytokines associated with sepsis, including interleukins, tumor necrosis factor, chemokines, high-mobility group proteins, and other molecules, play a key role in the inflammatory process of sepsis.