These allergic reactions include anaphylaxis, a severe life‐threatening systemic reaction due to mast cell degranulation and mediators' release, and cutaneous reactions including delayed large local reactions, urticaria, maculopapular rashes, chilblains, cosmetic filler reactions, pityriasis‐rosea‐like eruptions, etc. PEG and polysorbate 80, excipients that stabilize vaccine potency and help it induce a stronger immune response, can provoke IgE‐mediated reactions and are the main identified culprits for these hypersensitivity reactions. Here, IGHE is linked to hypersensitivity reaction disease.