CXCL8 and obesity due to melanocortin 4 receptor deficiency: Dietary and nutraceutical combination treatment group showed a significantly lowered level of IL-8 in serum compared to placebo, which might support the treatment of chronic inflammatory disorders (arthritis, diabetes, obesity, and osteoporosis) and common mental disorders (CMDs) i.e., depression, anxiety disorders, insomnia, and stress-related symptoms.