CRH and alcohol abuse: Alcohol use disorder is a complex dynamic process, involving adaptive changes related to the neuroendocrine system, neurotransmitters [γ-aminobutyric acid (GABA), glutamate, monoamines], neuropeptides [corticotropin releasing factor (CRF), neuropeptide Y (NPY)] and ion channels (voltage-gated ion channels, small-conductance Ca2+-activated K+ channel, big potassium ion channel).