CCL2 and Anxiety: IL-8 and MCP-1 were found to be significantly higher in AUD individuals with the presence of a mood (p = 0.003, p = 0.01, respectively) and anxiety (p = 0.04, p = 0.01, respectively) disorder and those who have poor sleep (p = 0.02, p = 0.04) (Figures 5A,B).