In a small cohort of pemphigoid gestationis patients, about half of the patients showed IgG reactivity with a least one recombinant protein of the intracellular domain of BP180 (72) and in linear IgA disease, IgG and IgA reactivity was detected in 8% (for both isotypes) of analyzed sera (85). The gene discussed is CD79A; the disease is pemphigoid gestationis.