Proteomic CSF profiling of MS patients revealed that proinflammatory cytokines (CXCL12, TNF, IFN, CXCL12, IL6, IL8, IL10) (75), and signature proteins involved in the complement, coagulation cascade (including fibrinogen) and iron homeostasis were elevated in patients with a high cortical lesion load (76). Here, IL10 is linked to myeloid sarcoma.