CXCL12 and myeloid sarcoma: Proteomic CSF profiling of MS patients revealed that proinflammatory cytokines (CXCL12, TNF, IFN, CXCL12, IL6, IL8, IL10) (75), and signature proteins involved in the complement, coagulation cascade (including fibrinogen) and iron homeostasis were elevated in patients with a high cortical lesion load (76).