In MCAO model mice, the NOX subunit p47phox expression was upregulated in microglia by ischemia, aggrandized the expression of Tnfa and edema progression. AHR antagonist can relieve hypoxia/ischemia and edema progression and improve the neurological severity scores in mice via inhibition of the AHR signaling pathway. The gene discussed is NCF1; the disease is ischemia.