TNF and arthritic joint disease: Treatment with Y-27632 significantly reduced the overexpression induced by arthritis except in the case of Tnfα, Cxcl5, Nos2 and Ccl2. The first three genes did not show a statistically significant regulation by Y-27632, although showed a trend to a more limited overexpression, although it was non-significant (p = 0.09; p = 0.13; p = 0.07, respectively).