PROM1 and hepatocellular carcinoma: During treatment, one patient had a partial response, 14 had a stable disease for 2 to 16.3 months, and six progressed after T-cell infusion; they found that hyperbilirubinemia was the most common high-grade adverse event and several circulating molecules, such as endothelial growth factor (VEGF), soluble VEGF receptor 2 (sVEGFR2), stromal cell-derived factor (SDF)-1, and interferon (IFN)-γ, could be the potential biomarkers of CD133 CAR-T therapy in HCC (59).