CD4 and metabolic dysfunction-associated steatohepatitis: Depletion of hepatic Foxp3+CD4+CD25+ Tregs may result in steatosis if the animals are fed with a high-fat diet, while reconstitution of Treg cells can attenuate the NASH phenotype, accompanied by the reduction of hepatic inflammation as evidenced by a downregulation in hepatic TNFα expression (99).