CD4 and metabolic dysfunction-associated steatohepatitis: Significantly increased levels of MHCII were also observed in the liver samples of patients with alcoholic hepatitis (AH), with marked upregulation of CD4 expression closely associated with MHC II producing hepatocytes in AH biopsies (52), suggesting that hepatocytes may function as important nonclassic APCs in NASH-related liver fibrosis.