It has been reported that functional IL-13Rα2 was upregulated in activated hepatic stellate cells (HSCs) in NASH, and IL-13 cytotoxin-mediated killing of IL-13Rα2+ cells can ameliorate liver fibrosis in a rat model of NASH, indicating the involvement of the IL-13/IL-13Rα2 pathway in NASH (71). This evidence concerns the gene IL13 and metabolic dysfunction-associated steatohepatitis.