GSDMD and breast cancer: Figure 1C and Table S4 visualized the location of CNV changes in PCDAGs on the chromosome. Besides, we investigated the transcriptional change of PCDAGs between BC and normal samples and discovered that PCDAGs with CNV amplification, such as GSDMC, GSDMD, and ZBP1, exhibited higher expression in BC samples compared with normal ones, while PCDAGs with CNV loss, such as GPX4, ACSL4, and NLRP1, displayed reduced expression in tumor ones (Figures 1B, D), demonstrating that CNV might participate in the regulation of PCDAG expression.