NLRP3 and melanoma: Specifically, transcriptomic analysis in M-MDSCs revealed 992 DEGs (|FC| ≥ 1.5, FDR< 0.05) between Nlrp3-/- and WT melanoma-bearing animals (Figure 5A) with 318 and 674 genes to be up- and downregulated, respectively (Supplementary Figure 6B).