Regarding the G-MDSCs, differential expression analysis revealed 1,521 DEGs (|FC| > 1.5, FDR< 0.05) between tumor-bearing Nlrp3-deficient and WT mice (Figure 6A), with 466 and 1,055 genes to be up- and downregulated, respectively (Supplementary Figure 6B). This evidence concerns the gene NLRP3 and neoplasm.