ITGAX and neoplasm: Interestingly, CD11c–CD11b+Gr1+ MDSCs frequencies were comparable between WT and Nlrp3-/- mice (Figure 3A), whereas assessment of MDSC subsets revealed an increased accumulation of CD11bhighLy6C+Ly6G– M-MDSCs and markedly decreased levels of CD11bhighLy6C–Ly6G+ G-MDSCs into the tumor site of Nlrp3-/- mice (Figure 3B).