NLRP3 and neoplasm: Flow cytometry analysis demonstrated robust expression of NLRP3 and pro-IL-1β in MDSCs from spleens of naïve mice (Figure 4E) as well as in highly pure MDSCs isolated from tumor-bearing mice (Figure 4F), and this is accompanied by increased levels of secreted IL-1β as determined in culture supernatants (Figure 4G).