NLRP3 and neoplasm: Based on the established expression of NLRP3 in the myeloid compartment (31) combined with the enhanced accumulation of MDSCs compared to other myeloid cell subsets in the TME (Figure 4A and Supplementary Figure 4A) and the extended re-arrangement of MDSC subsets in the tumor-inoculated Nlrp3-/- mice, we sought to determine the NLRP3 and pro-IL-1β expression in the MDSC population during tumor development.