NLRP3 and COVID-19: Male patients had higher levels of serum miRNAs implicated in pro-inflammatory responses (such as miR-miR-21-5p, miR-320a-3p, miR-101-3p) and lower levels of serum miR-223-3p, which was downregulated in COVID-19 patients and identified as a negative regulator of pro-inflammatory cytokine secretion and NLRP3 inflammasome activation in the lung of SARS-CoV-2 infected mice (15).