For example, abnormal levels of several clinical and laboratory parameters, such as renal dysfunction, elevated C reactive protein (CRP) and D-dimer levels, high serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were identified as predictors of worsening outcome in COVID-19 (4, 5). Here, CRP is linked to Abnormal renal physiology.