MiRNAs that were downregulated in serum of COVID-19 patients mainly target genes promoting angiogenesis (e.g., VEGFA, ANGPT2, COL4A1, FGF2, ZEB1), apoptosis, autophagy, stress response (e.g., ATG12, ATG14, ATG2B, SOD2, TXNIP), and inflammation (e.g., CXCL9, CXCL10, IL1R1, TNF). This evidence concerns the gene IL1R1 and COVID-19.