The canonical pathways that were inhibited/decreased included the ICOS-ICOSL Signaling in T helper cells, and TGF-β Signaling, PKCβ Signaling in T lymphocytes, Systemic Lupus Erythematosus In T Cell Signaling Pathway, and STAT3 Pathway (Table 2). The gene discussed is ICOSLG; the disease is systemic lupus erythematosus.