IL-18 levels are usually elevated in psoriasis (7), systemic lupus erythematosus (SLE) (8, 9), hypertension, chronic kidney disease (10), multiple sclerosis (MS) patients (11, 12) and Coronavirus disease 2019 (COVID-19) (13, 14) which correlates with caspase-1 levels (15). The gene discussed is CASP1; the disease is psoriasis.