Interestingly, a deficiency in NLRP6 inflammasome, a known regulator of colonic homeostasis predominantly found in intestinal epithelial cells, is detrimental in dextran sodium sulfate (DSS) induced colitis (DSS is a frequently used mouse model for colitis in which drinking water spiked with DSS injures the intestinal epithelium like IL-18 deficiency) (169). This evidence concerns the gene NLRP6 and colitis.