CD8A and neoplasm: In addition, one of the key findings of PetrosX et al., who investigated the combination of thermal ablation and ICIs, was that this combination of therapies induces a local tumor pro-inflammatory microenvironment, which is evidenced by the increased infiltration and proportion of several types of inflammatory cells (CD8+TIL, CD8+ IFN γ + TIL, and CD4+T cells) 48 hours after treatment.