found that mild hyperthermia not only activated macrophages and DCs in tumors but also improved the structure of tumor vessels by reducing the levels of transforming growth factor-β (TGF-β) and hypoxia-inducible factor-1 α (HIF-1α) and significantly increased the proportion of CD8+IFN- γ + T cells (44). This evidence concerns the gene TGFB1 and neoplasm.