CD8A and neoplasm: In addition, recent studies have found that exosomes extracted from heat-stressed tumor cells (HS-TEX) can reverse immunosuppressive TME from the following four aspects, including: 1 activation of DCs;2 as a cancer vaccine promotes IL-6;3 secretion by cells to reduce the proportion of Treg and MDSCs, while increasing the proportion of Th1 and Th17;4 promote the differentiation of CD8+T cells (60–62).