Therefore, several studies propose a therapeutic strategy of TILs infiltration in tumor microenvironment (60), up-regulated expression of PD-L1 and combined with ICIs after thermal ablation or mild hyperthermia, to investigate whether these therapies could elicit stronger and more lasting systemic immunity in tumor patients to resolve recurrence and distant metastasis after hyperthermia (Figure 1). Here, CD274 is linked to neoplasm.