CD8A and melanoma: To identify a possible hierarchical dominance between peptide:HLA Ki and TCR-peptide:HLA KD affinities in the control of T cell functional avidity, we took advantage of a panel of primary CD8 T cells expressing NY-ESO-1157-165-specific TCRs isolated from LAU155, a long-term melanoma survivor (57) and engineered from the natural TCC9 Vb13.1 TCR to have incremental affinities for the peptide:HLA complex (44, 45).