However, as natural tumor-primed CD8 TILN clones showed much broader and variable reactivities toward the Melan-A/MART-126-35 peptide variants (Figure 3C), resulting in heterogenous linear regression slopes (Figure 3E), the R square correlative value as well as the average best-fit slope were weaker (Figure 3D). The gene discussed is CD8A; the disease is neoplasm.