Upon activation depending on the type of the inflammatory reaction and the strength of T cell receptor (TcR) signaling CD4+ T cells differentiate into different subsets, i.e., Th1 cells, which promote CD8+ T cell responses, Th2 cells,which drive B cell activation, Th17 cells, which induce strong inflammatory responses and activate neutrophiles, Th22 cells, which play a role in protecting skin against infections and regulatory T cells (Tregs), which dampen effector T cell responses and are crucial to maintain tolerance against self-antigens (32, 33). This evidence concerns the gene CD8A and infection.