CLN5 and colitis: Re-analysis of the same data in the context of a pan-tissue inflammatory framework revealed the persistence of the same pan-tissue homeostatic fibroblasts, and further identified the emergence of an Lrcc15+ myofibroblast-specific subset and a “colitis-specific” Adamdec1+ subset with increased Grem1 and Il11 expression, which also included BMPs, Mmp3 and Timp3 (15).