Identification of specific macrophage and conventional dendritic cell (cDC) subsets as key mediators of cellular crosstalk in the TIMEDiscovery of conserved myeloid subsets in human and murine CRC:a) Two distinct TAM subsets with inflammatory and angiogenic signaturesb) Two distinct TAM subsets with differential sensitivity to CSF1R blockadeActivation of specific cDC1s; expansion of Th1-like and CD8+ memory T cells via anti-CD40. Here, CD8A is linked to colorectal carcinoma.