Many scRNA-seq studies have found a link between significant infiltration of CD8+ T cells (45), CD4+ T helper 1 (Th1) (46), regulatory T (Treg) cells (47), tumor-infiltrating exhausted T cells (48), CD45+ macrophages, dendritic cells, and myeloid cells (49), and a favourable outcome in mCRC. Here, CD4 is linked to neoplasm.