CD79A and neoplasm: In the same year, Lee and their co-workers further explored the TIME, including six immune cells (epithelial, stromal, myeloid, T, B, and mast cells) and their matched normal mucosa, followed by an illustration of an immune transcriptional landscape and reconstruction of putative interaction network between tumor cells and their surrounding microenvironment via the dominance of IgA-type humoral immunity in normal mucosa and γδ T-cell-driven innate immunity in CRC (56).