Conversion of TIME into functionally inflamed immune hub via the concerted action of highly functional CD8+ EMT6 T cells and activated neutrophils drive M1-like TAM polarization, leading to complete tumor eradicationFacilitation of Entinostat in the accumulation of the necrosis-targeted recombinant murine immune-cytokine, NHS-rmIL12, in experimental mouse colon carcinomas and poorly immunogenic breast tumors. This evidence concerns the gene CD8A and colon carcinoma.