Identification of B cells from early CRC tumor to be pre-B like expressing tumor suppressors, and the full development of plasma cells from B cells in advanced CRC tumorsSupremacy of B and myeloid cells in immunoregulatory functions in CRC over CD4+ Treg cellsDiscovery of the interplay between T, B and myeloid cells:a) B-cell/CD52+ myeloid-cell interaction- Inhibition of SIGLEC10+ T cells activationb) CCL8+ cycling B-cell/CCR5+ T-cell and IgA+IGLC2+ plasma-cell/CCR5+ T-cell interactions-Recruitment of CCR5+ T-cell to tumor lesions. The gene discussed is CD4; the disease is neoplasm.