Recently, tissue-resident macrophages (TRMs), which express canonical macrophage genes, including mannose receptor C-type 1 (MRC1), C1QA, CD68, and apolipoprotein (APOE), but lack a monocytic signature, have been described in early-stage, treatment-naïve NSCLC (101). Here, MRC1 is linked to non-small cell lung carcinoma.