Research has shown that ER stress not only directly regulates vascular endothelial cells (VECs), but also induces HNSCC cells to release mir-424-5P contained in EVs, which inhibits the expression of laminin gamma 1 (LAMC1) (23), a protein essential for the assembly of basement membranes as well as tumor angiogenesis and development. Here, LAMC1 is linked to neoplasm.