YAP1 and cancer: It has been established that contact between cancer cells and fibroblasts can promote the CAF phenotype in cancer through a variety of signaling pathways, such as Notch signaling, inflammatory signaling, Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling, and Yes-associated protein/Transcriptional enhanced associate domain (YAP1/TEAD) signaling (21).