In myocardial infarction model, Leucine Rich Repeat Containing G Protein-Coupled538 Receptor 4 (Lgr4)-mediated cAMP/PKA/CREB pathway promotes transactivation of Fos in pro-inflammatory macrophage to enhance AP-1 activity, thereby triggering proinflammatory programming in macrophages to coordinate the proinflammatory state of infarcted macrophages (101). The gene discussed is FOS; the disease is myocardial infarction.