RNF213 and neoplasm: Prokineticin 2(PROK2)is an important contributor to tumor angiogenesis (151), Ring Finger Protein 213 (RNF213) is essential for normal vascular development (152), and Leucine Rich Alpha-2-Glycoprotein 1 (LRG1) plays a role in retinal vascularization abnormalities observed in oxygen-induced retinopathy (154).