It also promoted the differentiation of monocytes/macrophages into osteoclasts at the same time, thus providing a favorable microenvironment for the colonization and growth of breast cancer cells in bone (104); The cytokine IL-6 induces Fra-1 deacetylation, then promoting colorectal cancer stem-like properties (74); In addition, the existence of an aberrant IL-6/STAT3/Fra-1 signaling axis leading to colorectal cancer(CRC) aggressiveness through EMT induction, which suggests novel therapeutic opportunities for the malignant disease (55). Here, IL6 is linked to colorectal cancer.