Inflammation markers that increase significantly with greater likelihood of AD diagnosis as defined by increasing PLM class (ANOVA, p < 0.001) include: hepatocyte growth factor (HGF), matrix metalloproteinase-10 (MMP-10), tumor necrosis factor superfamily member 12 (TWEAK), and adenosine deaminase (ADA). The gene discussed is TNFSF12; the disease is Alzheimer disease.