Examples include interventions for hypertension control (angiotensin-converting enzyme inhibitor therapy for intensive compared with standard hypertension control); multicomponent interventions for diabetic risk factors control and early detection of complications, compared with standard glycemic control for persons with T2D; intensive lifestyle interventions to prevent T2D among persons with impaired glucose tolerance, compared with standard lifestyle recommendations; annual screening for diabetic retinopathy and ensuing treatment in persons with T2D, compared with no screening.14 The gene discussed is ACE; the disease is diabetic retinopathy.