As a result, the shift from G1 to S-phase was accelerated [36], CDK2 was considerably downregulated and the commencement of the transition from G1 to S-phase was similarly suppressed after HOXC-AS3 knockdown, which explained the G1 arrest of HCC cells after HOXC-AS3 knockdown. The gene discussed is CDK2; the disease is hepatocellular carcinoma.