The Wnt/β-catenin pathway influences insulin action and systemic glucose homeostasis.252,253 The canonical Wnt transcriptional effector TCF7L2 was found to be closely related to susceptibility to T2D.254 In visceral adipose tissues of patients with obesity-related diabetes and HDF-fed mice, the Wnt/β-catenin pathway is downregulated. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.