MAPK8 and obesity due to melanocortin 4 receptor deficiency: Inhibition of CXXC-type zinc-finger protein 5 (CXXC5), a negative feedback regulator of Wnt signaling, alleviates the phenotype of obesity-related diabetes.255 Wnt signaling induces the synthesis of incretins within the small intestinal epithelium and is linked to T2D.256 In addition, Wnt5a, a part of the noncanonical Wnt pathway, has been proven to induce obesity-associated inflammation in WAT and contribute to dysregulation in glucose metabolism in a JNK-dependent manner.257