CGAS and obesity due to melanocortin 4 receptor deficiency: Of note, adipose tissue-specific knockout of DsbA-L, a chaperone-like protein identified in the mitochondrial matrix that maintains mitochondrial integrity, activates the cGAS-STING pathway in adipose tissue and exacerbates obesity-related pathology, while fat-specific overexpression of DsbA-L protected mice against HFD-induced activation of the STING pathway and chronic inflammation.313 These results suggest that maintaining mitochondrial homeostasis to target STING activation may be an alternative anti-obesity strategy.