H-type vessels (CD31hiEmcnhi vessels) are involved in osteogenesis.16,17 Previously, we found that PDGFR-β signaling promotes H-type vessel formation in osteoporosis.24 Thus, we explored the correlation between the PDGFR-β level and CD31hiEmcnhi endothelial cells (ECs). The gene discussed is PDGFRB; the disease is osteoporosis.