Unlike NSCLC patients with other common molecular aberrations, who have a remarkable response to tyrosine kinase inhibitors (TKIs), HER2-altered patients are relatively insensitive to HER2-targeted TKIs such as afatinib, neratinib, poziotinib, and dacomitinib, with an objective response rate (ORR) of less than 30% [7–10]. Here, ERBB2 is linked to non-small cell lung carcinoma.