As per previous reports, poor antitumor activity was observed with single-agent afatinib, dacomitinib, and neratinib in advanced NSCLC with HER2 mutations, with an ORR of only 3.8%-12.0% and a median PFS of 3–5.5 months [7, 9, 10]. Here, ERBB2 is linked to non-small cell lung carcinoma.