ERBB2 and non-small cell lung carcinoma: Subgroup analysis showed that comparable responses were observed in patients receiving pyrotinib plus apatinib either as second-line or as third- or above-line therapy, while patients treated with this regimen as second-line therapy had better PFS than those treated with this regimen as third- or above-line therapy (9.8 vs. 6.1 months), which might indicate pyrotinib plus apatinib might be more efficacious in earlier lines for HER2-altered NSCLC patients; however, more studies on this topic are needed.