ERBB2 and non-small cell lung carcinoma: Currently, only two anti-HER2 antibody–drug conjugates (ADCs), ado-trastuzumab emtansine (T-DM1) and trastuzumab deruxtecan (DS-8201), have shown encouraging results in HER2-mutated NSCLC, with an ORR of 44–55% [14, 15].