TLR7 and neoplasm: TDEs also engage with other TLRs such as TLR4 and TLR7 on other phagocytes including monocytes and neutrophils in which miRNA, noncoding RNA, and high-mobility group box 1 (HMGB1) transferred by TDEs are implicated in driving the pro-tumor phenotype of these myeloid cells [48–50].