TRCs express less Cdc42 than differentiated tumor cells and Cdc42 regulates TRC stiffness,[8] spreading,[33] and softness‐dependent extravasation in vivo.[34] In addition, TRCs express low focal adhesion kinase (FAK) and downregulate H3K9 methylation through reduction of Cdc42 and RhoA[35] that promotes TRC growth via Sox2‐dependent self‐renewal.[8] Currently, it is unclear how the downregulated Cdc42 and lower tractions by WYC‐209 induces chromatin decondensation. The gene discussed is CDC42; the disease is neoplasm.