TAPC‐4, an amphiphilic aminated [60]fullerene with a well‐defined structure, prevents tumor growth and metastasis by blocking the cell cycle in G0/G1 phase, reversing the epithelial‐mesenchymal transition process, and regulating the localization of myosin heavy chain 9, which may be achieved by binding against specific proteins. This evidence concerns the gene MYH9 and neoplasm.