PFKFB3 and malignant colon neoplasm: In general, the overexpression of GLUT1 (HR = 1.57, 95% CI: 1.22–2.02, P = 0.001) and PFKFB3 (HR = 1.60, 95% CI: 1.13–2.27, P = 0.009) indicated poor outcomes, whereas OXCT1 (HR = 0.76, 95% CI: 0.58–0.98, P = 0.036) and ACAT1 (HR = 0.77, 95% CI: 0.61–0.99, P = 0.037) indicated favorable overall survival for patients with colon cancer (Figure 1C).