Comparison of the gene expression scores revealed in tumor tissues a decrease of the ketolytic enzyme acetyl‐CoA acetyltransferase (ACAT1) and a trend of decrease in 3‐oxoacid CoA‐transferase 1 (OXCT1) and d‐β‐hydroxybutyrate dehydrogenase (BDH1), along with low expression of the oxidative phosphorylation (OXPHOS) factor peroxisome proliferator activated receptor γ coactivator‐1α (PGC‐1α) (Figure 1A, upper panel). This evidence concerns the gene BDH1 and neoplasm.