PFKFB3 and colonic neoplasm: Using univariate Cox regression analysis and the least absolute shrinkage and selection operator (LASSO) of the above identified genes, we identified two glycolytic enzymes (GLUT1 and PFKFB3) (Figure S1A, Supporting Information), which, together with the two ketolytic enzymes (OXCT1 and ACAT1), constitute a molecular signature of colon cancer prognosis in the context of ketogenic diet (Figure S1B, Supporting Information).