Totally 40 patient‐derived colon cancer tissues were subjected to metabolic subtyping by multiplex immunostaining of the corresponding PDX sections, ten of which were identified as glycolytic subtypes (G+/K−) as manifested by low/absent expression of OXCT1 or ACAT1, as well as high expression of GLUT1 or PFKFB3, two of which were identified as ketolytic subtypes (G+/K+) with all of the four genes overexpressed (Figure 2A,B). The gene discussed is ACAT1; the disease is colonic neoplasm.