In this context, we show that the SAC regulating protein Trip13 is commonly increased in mouse and human HCC as compared to normal livers, which is in agreement with previous reports from various cancer entities.[16] Moreover, we demonstrate that Trip13 depletion in proliferating HCC cells strongly interferes with mitosis, causing aberrations in spindle formation, mitotic arrest, and eventually mitotic cell death. This evidence concerns the gene ADCY10 and hepatocellular carcinoma.