In congruence with our previous results in HCC cells, the reduction in cell growth upon KD of Trip13 in SK‐BR3 was associated with increased lipid droplet accumulation and mitotic arrest (Figure 6D,E), suggesting that induction of cell death by Trip13 KD was not necessarily determined by its basal levels in different tumor entities. The gene discussed is TRIP13; the disease is hepatocellular carcinoma.